Abstract: Introduction: Bioresonance is a holistic physical method that can be used diagnostically and therapeutically to treat various diseases. Bioresonance uses the electromagnetic waves it receives from the patient. This biophysical method of treatment alters the energy field of the affected organism, increasing the effectiveness of the autoimmune system, thus improving the patient’s overall health. Methods: A quasi-experimental design was used to examine whether bioresonance had an effect on the symptoms of the patients. Statistical data processing involves a study of various parameters such as age, gender, studies, occupation, intolerance or illness as well as the existence and balancing of allergic charges. The study included 311 patients from doctors and bio-coordinating laboratories in Athens, Thessaloniki, Volos and Xanthi. The sample of the study included both men (120 subjects - 38.58%) and women (191 subjects – 61.42%), aged from 2 to 76 years old. The age group with the largest number of patients included those aged from 31 to 45. Results: The patients under treatment came forward with symptoms mostly nasal (61.09%), followed by eye, respiratory, cutaneous, and gastrointestinal symptoms. Most of the patients (90%) observe no symptoms at all or show significant improvement of their symptoms after a period of 12 months of bioresonance treatment. These results show that bioresonance intervention had a significant effect on the improvement of symptoms and this improvement is even obvious 12 months after the intervention; p<.01. Conclusion: We believe that the forthcoming results contribute to a better understanding of the effect of bioresonance on the human body and its affect in preventing and restoring health issues